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pyrH [2019-08-01 11:19:24]
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pyrH [2019-08-01 11:19:24]

uridylate kinase
Locus
BSU_16510
Isoelectric point
5.10
Molecular weight
25.93 kDa
Protein length
240 aa Sequence Blast
Gene length
723 bp Sequence Blast
Function
pyrimidine biosynthesis
Product
uridylate kinase
Essential
yes
E.C.
2.7.4.22
Synonyms
smbA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Nucleotide metabolism → Biosynthesis/ acquisition of nucleotides → Biosynthesis/ acquisition of pyrimidine nucleotides
  • Groups of genes → Essential genes

    • Gene

    Coordinates
    1,719,802 1,720,524

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + UMP = ADP + UDP (according to Swiss-Prot)

    • Protein family

  • UMP kinase family (single member, according to UniProt)

    • Structure

  • 2JJX (from Bacillus anthracis, 42% identity, 64% similarity) PubMed

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    rpsB-tsf-pyrH-frr
    Description
    PubMed

    Regulatory mechanism

  • stringent response: negative regulation, PubMed, in stringent response

    • Regulation

  • RelA dependent downregulation (Class I) during stringent response PubMed
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    References

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