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pyrH [2019-08-01 11:19:24]
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pyrH [2019-08-01 11:19:24]

uridylate kinase
locus
BSU_16510
pI
5.10
mw
25.93 kDa
protein length
240 aa Sequence Blast
gene length
723 bp Sequence Blast
function
pyrimidine biosynthesis
product
uridylate kinase
essential
yes
ec
2.7.4.22
synonyms
smbA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    1,719,802 1,720,524

    Phenotypes of a mutant

  • essential [Pubmed|28189581]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + UMP = ADP + UDP (according to Swiss-Prot)

    • Protein family

  • UMP kinase family (single member, according to UniProt)

    • Structure

  • [PDB|2JJX] (from ''Bacillus anthracis'', 42% identity, 64% similarity) [Pubmed|18625239]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB]-[gene|94E1130A787CBCCCDBDA93C8AFC24ECB82D5FE61|tsf]-[gene|40655595D0C573B4CB75FB255CBB01A6ACF1F94D|pyrH]-[gene|093960C48AD50C0D0B3A68BBFE7D060BE716935D|frr]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, [pubmed|11948165], in [regulon|stringent response|stringent response]

    • regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
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    References

  • 12869195,8206849,1709162,28189581